The relationship between ghrelin and GERD is indicated by its action within the gastrointestinal tract and from observations in an animal model, as well as a study by Agrawal et al., where, after administration of ghrelin and capromorelin (a ghrelin agonist), a reduction in the number of reflux episodes was seen when compared to placebo [49,64]. This evidence concerns the gene GHRL and gastroesophageal reflux disease.