Angiopoietin(Ang)-2 and von Willebrand factor (vWF) are both regarded as markers of endothelial activation, and systemic levels of both these markers are increased in patients with severe CRS both before lymphodepletion (i.e., signs of endothelial activation before the treatment) and during the development of CRS [6] (Figure 1). This evidence concerns the gene VWF and congenital rubella syndrome.