His disease course was refractory to azathioprine, anti-TNFα, and cyclosporin A. Two years and eight weeks after stopping azathioprine, but continuing infliximab therapy, he presented with fever, lymphadenopathies, splenomegaly, anemia, leucopenia, and ferritinemia (4361 μg/L). The gene discussed is TNF; the disease is anemia (phenotype).