INS and major depressive disorder: Female sex; older age; comorbidities, namely ischemic heart disease, diabetes mellitus, atrial fibrillation, chronic heart failure, peripheral arterial disease, asthma, chronic obstructive pulmonary disease (COPD), major depressive disorder, Parkinson’s disease, rheumatoid arthritis, and insomnia; and use of antiplatelet agents, benzodiazepines, anticoagulants, NSAIDs, acetaminophen, insulin, calcium channel blockers, diuretics, and metformin were determined to be significant risk factors for dementia.