Therefore, this study aimed to evaluate the prevalence and magnitude of the immune response against different highly immunogen microbial peptides derived from P. gingivalis (RgpA, Kpg), A. actinomycetecomitans (LtxA-1, LtxA-2) MAP (MAP_402718–32), EBV (EBNA1400–413, BOLF1305–320), and HERV-W env-su 93–108 in RA patients compared with the general population. The gene discussed is ERVW-1; the disease is rheumatoid arthritis.