Regression analyses of hormonal parameters with fMRI activity in PWS patients watching food versus non-food pictures showed a significant negative correlation with glucose in the right amygdala (24, –3, –21; Z = 3.24; p_fwe = 0.007); for leptin, we observed a positive correlation in the right anterior hippocampus/amygdala (24, –12, –12; Z = 3.59, p_fwe = 0.028). Here, LEP is linked to Prader-Willi syndrome.