TIMP2 and acute kidney injury: In the protocol implementation cohort, [TIMP2 × IGFBP7] was measured in all patients at ICU admission: 46 (32.2%) patients had a low AKI risk (TIMP2 × IGFBP7 < 0.3), 81 (56.6%) had a moderate AKI risk (TIMP2 × IGFBP7 0.3–2.0), and 16 patients (11.2%) had a high AKI risk (TIMP2 × IGFBP7 > 2).