CD86 and systemic lupus erythematosus: Furthermore, our in silico analysis confirmed the implication of miR-34a in the SLE pathway (Figure 1 and Table S1) by targeting several genes coding for different histone family proteins, RNA-binding proteins, including the spliceosome small nuclear ribonucleoproteins, and several immune response-related proteins as CD86, CD40, and HLA class II histocompatibility antigen; DM alpha chain (Table S1).