When looking at this issue in the context of nephrological complications, attention should be given to the linear correlations between PAI-1 and eGFR as well as to those between sE-SELECTIN and eGFR, as such results may suggest a certain advantage of PAI-1 and sE-SELECTIN over the other endothelial dysfunction markers, especially regarding the identification of early changes in the kidneys. Here, SERPINE1 is linked to endothelial dysfunction.