Copy number variants (CNVs) involving deletions of the RORB gene have been described to be associated with epilepsy and mild intellectual disability by Baglietto and colleagues [14]; intellectual disability, speech delay, epilepsy, and dysmorphic traits by Boundry-Labis and colleagues [15] and developmental delay and ADHD by Tug et al. (2018). This evidence concerns the gene RORB and attention deficit-hyperactivity disorder.