In a study of cell lines (V10R) RPMI 8226, OPM-2, ANBL-6 and KAS-6/1, Li et al. report an increase in POMP protein expression in MM cells resistant to bortezomib [17]; they also found the suppression of POMP protein via shRNAs to restore cell sensitivity, while its over-expression in cells not subject to prior treatment increased resistance. The gene discussed is POMP; the disease is Miyoshi myopathy.