Apigenin significantly decreases IKK activity, IκBα phosphorylation and degradation, and nuclear NF-κB, leading to the down-regulation of many NF-κB-regulating genes, such as Bcl2, COX-2, MMP-9, NOS-2, and VEGF, which sensitize hormone-refractory cancer cells to TNFα-induced apoptosis [89]. The gene discussed is NFKB1; the disease is cancer.