The etiopathogenesis of SLE is still unclear, and it is characterized by a strong genetic predisposition, with specific haplotypes of the human leukocyte antigen (HLA) region, i.e., HLA-DRB1 (DRB1*1501 and DRB1*0301), and a concomitant co-factor that triggers the autoimmune response [5,6]. Here, HLA-DRB1 is linked to systemic lupus erythematosus.