As a result of these multivariable GAM, smooth spline estimates of the primary composite endpoint (all-cause death or HF hospitalization, Figure 3) and the secondary endpoint (all-cause death, Supplementary Figure S2) according to blood gene expression of ADM, ECE1, FTMT, SIRT7, SMIM20 and TFRC were plotted. Here, SMIM20 is linked to hydrops fetalis.