CRP and COVID-19: This recommendation was maintained by the NIH guidelines with a specific indication in favor of TCZ plus steroids [51], confirming the setting of patients with severe COVID-19, and was in line with the recommendation of REMAP-CAP [23] in addition to RECOVERY [28], and was consistent with definitions of progressive disease and marked pro-inflammatory status based on concentrations of C-reactive protein (CRP) being higher than 75 mg/L, a threshold established in the RECOVERY study [28].