SERPINE1 and familial hyperaldosteronism: For this reason, P-selectin, E-selectin, I-CAM-1, V-CAM-1, von Willebrand factor, thrombomodulin, plasminogen activator inhibitor-1 (PAI-1) plasma levels, hs-CRP and PAI-1/tPA ratio are the most investigated BM measuring EC dysfunction in FH patients.