As shown in Table 2, after adjusting for the covariances (SAE or non-SAE group, age, gender, BMI, overweight, obesity, diabetes, HBV viral load, PT prolongation, HBeAg positivity, NA therapy duration, NA consolidation duration, NA consolidation > 36 months, NA categories, pre-treatment and post-treatment bilirubin, AST and ALT), male gender (hazard ratio (HR) 2.31, 95% CI: 1.13–4.75; p = 0.022), and SAE-group (HR 1.79, 95% CI: 1.04–3.06; p = 0.034), were all independent factors for severe CR. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.