Homozygous LmnaΔ8–11/Δ8–11 mice, first thought to be a knock-out (KO) model for Lmna, display growth retardation, skeletal dystrophy and DCM-CD characterized by left ventricular (LV) dilatation and reduced systolic contraction, and die around 8 weeks of age due to the expression of a truncated lamin A mutant at low level [25,47]. The gene discussed is LMNA; the disease is familial dilated cardiomyopathy.