LMNA mutations are the most common gene defect responsible for lipodystrophy syndrome of Dunnigan type (type 2 Familial Partial Lipodystrophy or FPLD2), characterized by lack of adipose tissue in the four limbs and its accumulation within the neck and the face, accompanied by metabolic abnormalities. This evidence concerns the gene LMNA and familial partial lipodystrophy, Dunnigan type.