Inhibition of TGF-β signaling was also tested in another mouse model: the Lmna-DCM mice, an inducible and cardiomyocyte-specific model of lamin A/C depletion created by Tan et al. by AAV delivery of shRNA targeting Lmna mRNA under cardiac specific promoter in 1.5-week-old mice. The gene discussed is TGFB1; the disease is familial dilated cardiomyopathy.