LMNA and Emery-Dreifuss muscular dystrophy: Transcriptome and secretome analyses revealed the hyperactivation of TGF-β signaling in hearts of LmnaH222P/H222P mice, prior to the onset of the cardiac disease and leading to elevated TGF-β2 levels in the majority of the patients (EDMD and LGMD1B and other neuromuscular diseases) and in LmnaH222P/H222P mouse sera [80,92].