In addition, in a recent study using a rat model to study AP, Ventimiglia and colleagues described a protective role of atrial natriuretic factor (ANF) mediated by cAMP extrusion through ABCC4 and suggested that the regulation of ABCC4 by ANF could be relevant to maintaining pancreatic acinar cell homeostasis [44]. The gene discussed is NPPA; the disease is alkaline phosphatase measurement.