CTRC and alkaline phosphatase measurement: We investigated all SNVs present on our array platform that were located on or in the vicinity of those genes previously associated with changes in susceptibility to pancreatitis, including CFTR, CTRC, PRSS2, SPINK1, CASR, and the recently reported variants in AP-associated carboxypeptidase A2-encoding gene CPA2, in unc-51 like autophagy activating kinase 2-encoding gene ULK2, and in serine protease 1-encoding gene PRSS1 [20,21,22] but could not replicate any of the previously described significant associations (Table S3).