CD4 and myelodysplastic syndrome: Different studies have highlighted the relevance of bone marrow immune microenvironment in myelodysplastic syndromes, suggesting a possible mediated “autoimmune” etiopathogenetic role in some cases or a correlation between certain T-cell subtypes and disease aggressiveness, such as CD4+ and T-reg cells which may lead disease progression through a reduction of anti-neoplastic response [18].