In previous studies, CDDO derivates can regulate the signal transmission of Keap1-Nrf2, NFKB, and the STATs pathway, and then achieve anti-oxidation, anti-inflammatory and even anti-cancer effects, and the interaction between the signal pathways are quite close and complicated (Saha et al., 2020, Krajka-Kuźniak and Baer-Dubowska, 2021). The gene discussed is NFKB1; the disease is cancer.