Regulons of TFs related to MN homeostasis and identity such as MNX1, ONECUT1, HOXA1, and HOXD8 were downregulated in sporadic ALS MNs and in the end-stage SOD1 G93A 129Sv MNs but not in MNs derived from ALS SOD1 iPSC (Figure S4C). The gene discussed is ONECUT1; the disease is amyotrophic lateral sclerosis.