Regulons of TFs related to MN homeostasis and identity such as MNX1, ONECUT1, HOXA1, and HOXD8 were downregulated in sporadic ALS MNs and in the end-stage SOD1 G93A 129Sv MNs but not in MNs derived from ALS SOD1 iPSC (Figure S4C). Here, HOXD8 is linked to amyotrophic lateral sclerosis.