Compared with control cells, AD‐VSMCs subjected to 30% mechanical tension showed decreased expression of VSMC contraction markers, including α‐SMA, SM22, and the expression levels of markers of contraction were also low (Figure 6A and B). In contrast, the expression levels of the VSMC secretion markers PCNA and OPN were higher under mechanical stretching than under static culture. Here, ACTA1 is linked to Alzheimer disease.