While insulin secretion during IPGTT is not changed between SUR1Δ/LDLR-/- and LDLR-/- mice at the age of 6 months, SUR1Δ/LDLR-/- mice fed with an additional 6 months of WD had significantly reduced insulin secretion when compared to LDLR-/- mice (Fig 4F–4H). Here, INS is linked to Wilson disease.