Additionally, as reported previously, while ascertainment of children with type 1 diabetes based on receipt of necessary insulin was previously validated as 95% accurate [28], ascertaining children with asthma [29], epilepsy [26], ADHD [25], depression [27], and skin disorders [30] via prescriptions has limitations because some medications are used for alternative reasons and not all children are medicated. The gene discussed is INS; the disease is major depressive disorder.