These common sites included the p97 ubiquitin-binding cofactor FAS-associated factor 2 (FAF2) (K167), the amyotrophic lateral sclerosis (ALS)–linked protein TAR DNA-binding protein 43 (TDP-43) (K181), the protein kinase AKT1 (K426), and Small ubiquitin-related modifier (SUMO) E3 ligase, Transcription intermediary factor 1-beta (TRIM28) (K320) (table S3 and fig. Here, TARDBP is linked to amyotrophic lateral sclerosis.