PINK1 and cancer: We have previously found that PINK1 activation leads to induction of phosphorylation of a subset of Rab GTPases including Rab8A at Ser111 in human cancer cell lines (31), and upon mitochondrial depolarization, we observed Ser111-phosphorylated Rab8A (phospho-Rab8A) in wild-type neurons, and this was abolished in PINK1 KO neurons (Fig. 1C).