While knockdown of MAPK6 (siRNA in proliferation assay and shRNA in soft-agar assays) or treatments using PP242 or INK128 each repressed AKT phosphorylation and PC3, H1299, and SUM159 cancer cell growth, including anchorage-independent growth, treatment of both achieved the most robust activity (Fig. 9, A to E, and fig. The gene discussed is MAPK6; the disease is cancer.