VEGFA and neoplasm: Using a transgenic mouse model with a standard chemically-induced skin carcinogenesis regimen, Hirakawa et al. have found that overexpressed VEGF-A in the skin not only strongly promotes multistep skin carcinogenesis, but also promotes active proliferation of VEGF receptor-2–expressing tumor-associated lymphatic vessels, and furthermore, tumor metastasis to the sentinel and distant lymph nodes.