However, parasite-specific and total IgE levels can be considerably increased in parasitic infections, e.g., 1360 ± 721 U/mL in urinary schistosomiasis or 2355 ng/mL (~973 IU/mL) in filarial tropical eosinophilia (Neva et al. 1975). This evidence concerns the gene IGHE and parasitic infectious disease.