Hence, not only can parasite-specific IgE be formed as early as one month after (primary) infection, the absence of detectable IgE levels in serum in the presence of basophil sensitization points to another relatively simple, but currently underexploited fact: That a cellular readout for parasite-specific IgE is possibly superior to traditional methods (such as ELISA) in terms of sensitivity. The gene discussed is IGHE; the disease is infection.