Microglial transcripts most highly positively associated with tissue amyloid-beta and tissue pTau density included those for genes associated with AD risk (APOE, MS4A6A and PILRA, Fig. 2 and Extended Data Fig. 7c,d, online resource), as well as those for genes associated with risks for other neurodegenerative disorders (LRRK2, SNCA and GPNMB, associated with Parkinson’s disease [8], and GRN, associated with ceroid lipofuscinosis [71] and frontotemporal dementia [4]). This evidence concerns the gene APOE and frontotemporal dementia.