In a review of 181 patients with germline BAP1 variants, the combined frequency of BAP1 null and missense variants among probands was the highest in uveal melanoma (60 of 181 [33%]), followed by cutaneous melanoma (51 of 181 [28%]) and mesothelioma (41 of 181 [23%]).1 In contrast, the incidence of RCC in this cohort was lower (12 of 181 [7%]; 4 of 40, and 8 of 121 probands with missense and null variants, respectively).1 The gene discussed is BAP1; the disease is uveal melanoma.