The first patient with a likely germline FLCN p.E335* alteration (identified on tumor-only sequencing, VAF: 50%) developed mesothelioma, which has been rarely reported in BHD patients.9 The second patient (with a germline FLCN p. H429fs* alteration) subsequently developed uveal melanoma and this case has been previously reported.8 This evidence concerns the gene FLCN and neoplasm.