Chloride intracellular channel (CLIC) proteins are novel Cl-channels with 6 family members (CLIC1–6) that are known to play crucial roles in multiple physiological functions, such as neurological, cardiovascular, pulmonary, and auditory functions, and in various malignancies, including hepatocellular carcinoma (HCC). Here, CLIC1 is linked to hepatocellular carcinoma.