GRP and early-onset autosomal dominant Alzheimer disease: Through finding differentially expressed genes (DEGs)between Tmem43S358L mutant and wild-type (Tmem43WT) lines,18 pathways (out of 42 found in BXDs GRP) that are involved in ARVC,hypertrophic cardiomyopathy, dilated cardiomyopathy, nonalcoholic fatty liverdisease, Alzheimer’s disease, Parkinson’s disease, andHuntington’s disease were verified.