As we found a significant correlation between Tmem43 with cardiomyopathy- andmetabolic-related traits in BXD strains and Tmem43 mutants, we performed geneticcorrelation analysis for the genes that have significant genetic correction withTmem43 in HCM, DCM, ARVC, NAFLD, and metabolic pathway (MP)and constructed a Tmem43-mediated gene network that is involvedin the development of cardiomyopathy and metabolic diseases. This evidence concerns the gene TMEM43 and metabolic disease.