To find genesthat could share the genetic regulator and have similar biologic function withTmem43, we performed genetic correlation and functionalenrichment analysis in BXDs and identified 42 Tmem43-mediatedpathways, 18 of those (42.8%) including cardiomyopathy-related (HCM, DCM, and ARVC),and metabolic-related (NAFLD) pathways have been confirmed through analysis of DEGsbetween Tmem43S358L and Tmem43WT mice. The gene discussed is TMEM43; the disease is familial dilated cardiomyopathy.