Through finding differentially expressed genes (DEGs)between Tmem43S358L mutant and wild-type (Tmem43WT) lines,18 pathways (out of 42 found in BXDs GRP) that are involved in ARVC,hypertrophic cardiomyopathy, dilated cardiomyopathy, nonalcoholic fatty liverdisease, Alzheimer’s disease, Parkinson’s disease, andHuntington’s disease were verified. The gene discussed is GRP; the disease is dilated cardiomyopathy.