As we found a significant correlation between Tmem43 with cardiomyopathy- andmetabolic-related traits in BXD strains and Tmem43 mutants, we performed geneticcorrelation analysis for the genes that have significant genetic correction withTmem43 in HCM, DCM, ARVC, NAFLD, and metabolic pathway (MP)and constructed a Tmem43-mediated gene network that is involvedin the development of cardiomyopathy and metabolic diseases. Here, TMEM43 is linked to arrhythmogenic right ventricular cardiomyopathy.