Further, KEGGpathway enrichment analysis found 48 enriched terms (FDR < 0.1), 18 of thosewere overlapped with the KEGG pathways enriched for the Tmem43covariates found in BXDs, including cardiomyopathy-, metabolic- andneurodegenerative-related pathways (Table1), suggesting that those pathways could be directly disturbed bychange in Tmem43 expression or induced by the S358Lmutation. This evidence concerns the gene TMEM43 and cardiomyopathy.