Therefore, we used the genes thatshowed a significant genetic correction with Tmem43 in HCM, DCM,ARVC, and NAFLD pathways among BXDs and DEGs between Tmem43S358L andTmem43WT mice to construct the Tmem43-mediated genenetwork shown in Fig. 5. The gene discussed is TMEM43; the disease is arrhythmogenic right ventricular cardiomyopathy.