We further identified five genes (Cacng6,Itga2, Ttn, Sgcg, and Tpm3)that are also involved in HCM-related pathways, seven genes (Adcy6,Gnas, Ttn, Cacng6, Itga2,Sgcg, and Tpm3) in DCM-related pathways,and four genes (Cacng6, Ctnna1,Itga2, and Sgcg) in ARVC-related pathwaysidentified in BXD strains had a significant expression change betweenTmem43WT and Tmem43S358L strains. The gene discussed is ADCY6; the disease is arrhythmogenic right ventricular cardiomyopathy.