Consistently, RA‐HFLS transfected with pcDNA‐COL5A2 vectors can weaken the Bcl‐2 expression and increase Bax, cleaved‐caspase‐3 expression, this alteration in the expressions of apoptosis‐related factors was reversed by the addition of miR‐1286 mimic in RA‐HFLS (Figure 6D). This evidence concerns the gene BAX and rheumatoid arthritis.