These Thr residues are conserved in vertebrates [31], and previous results indicate that equivalent mutations in the conserved Thr motif of mouse E2F4 (Thr249/Thr251) mitigate multiple processes that are altered in AD when this murine variant is expressed in neurons from 5xFAD transgenic mice using the Mapt promoter [19, 33]. The gene discussed is E2F4; the disease is Alzheimer disease.