Multiple, but not single, postnatal 6-day mice exposure to 3% sevoflurane 2 h daily induced phosphorylation of tau via GSK-3β activation, which increased the level of IL-6 and decreased the level of PSD-95 in the hippocampus, leading to cognitive impairment (Tao et al., 2014). This evidence concerns the gene DLG4 and Cognitive impairment.