Demethylzeylasteral promotes the degradation of c‐Myc through up‐regulating the expression level of FBXW7 (an E3 ubiquitin ligase) and consequent ubiquitylization of c‐Myc, which in turn inhibits cell proliferation, migration and invasion, and therefore, depresses the growth of gastric cancer. Here, FBXW7 is linked to gastric cancer.