FBXW7, an E3 ubiquitin ligase, is a recognized tumor suppressor that mediates the degradation of various proteins including c‐Myc, CyclinE, and MCL‐1, whereby playing pivotal parts in regulating cell cycle, DNA damage and repair, signal transduction and transcription factors in tumor cells, respectively.4, 12, 17. The gene discussed is MYC; the disease is neoplasm.