HCT116 shared fewer common targets with each of the other two cell lines, where 44 positively regulated genes and 23 negatively regulated genes were shared by HCT116 and RCC4 cells and only nine positively regulated genes and five negatively regulated genes were common between HCT116 and SKOV3ip.1 cells (Figure 1B), suggesting that KDM4B functional mechanism may be more similar in OVCAR and RCC rather than colon cancer. The gene discussed is KDM4B; the disease is malignant colon neoplasm.