Two of the 16 positively regulated genes, ERO1L and LOXL2, are involved in vascular endothelial growth factor (VEGF) secretion and extracellular matrix (ECM) remodeling, respectively, suggesting KDM4B is essential for the general malignant phenotypes that are shared by multiple cancers.26, 27. The gene discussed is LOXL2; the disease is cancer.