An inverse correlation was observed between the expression of PTEN and miR‐141‐3p, and miR‐141‐3p may contribute to the acquisition of chemoresistance in esophageal cancer cells by inhibiting the PTEN expression level to reduce apoptosis in vitro and in vivo, suggesting that the inhibition of miR‐141‐3p may reverse the occurrence of OXA resistance in esophageal cancer.225. This evidence concerns the gene PTEN and esophageal cancer.