Furthermore, a weakened spindle checkpoint with decreased expression of BubR1 but not of mitotic arrest deficient 2 (Mad2) promoted acquired Taxol resistance in ovarian carcinoma cells, and regulatory subunit associated protein 2 (CDK5RAP2) was found to regulate the transcription of key mitotic genes, such as BUBR1 and Mad2, to influence resistance to Taxol. This evidence concerns the gene BUB1B and ovarian carcinoma.