INS and systemic lupus erythematosus: KEGG pathways analysis between RA and SLE patients was also carried out, and following lipid metabolic pathways were changed such as metabolic pathways, glycerophospholipid metabolism, retrograde endocannabinoid signaling, insulin resistance, glycerolipid metabolism, fat digestion and absorption, and cholesterol metabolism (Figures 2C and 2D).