Recently, loss of function mutations on various negative regulators of the NF‐κB pathway in nearly half of NPC including NFKBIA, CYLD, TRAF3, TNFAIP3, and NLRC5 have been found by different groups using whole exome sequencing.36, 37, 38. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.