POU5F1 and neoplasm: Meanwhile, great efforts are also being devoted to replacing Yamanaka factors (OCT4, SOX2, KLF4, and c‐MYC) or Thomson factors (OCT4, SOX2, NANOG, and LIN28) that tightly associate with tumor progression by defined small molecules to achieve chemical induction of pluripotency (CIP).433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447