Moreover, a neurotoxicity of 1‐deoxysphingolipids raised by the expression of SPT variants, SPTLC1 and SPTLC2, also could account for rare autosomal dominant disorder, hereditary sensory and autonomic neuropathy type 1 (HSAN1).8 This evidence concerns the gene SPTLC2 and hereditary sensory and autonomic neuropathy type 1.