Other frequent events were alanine aminotransferase increase (0.143 95% CI 0.084, 0.232, I2 = 82%), anemia (0.135 95% CI 0.066, 0.256, I2 = 88%), diarrhea (0.127 95% CI 0.076, 0.204, I2 = 80%), and aspartate aminotransferase increase (0.102 95% CI 0.056, 0.181, I2 = 82%). The gene discussed is GPT; the disease is anemia (phenotype).