Numerous metabolites generated by de novo modification of cholesterol, such as mevalonic acid, farnesyl pyrophosphate (FPP), and geranylgeranyl pyrophosphate, are also important for cancer cell growth, based, in part, on the critical roles they play in oncogenic signaling pathways, such as the Hedgehog, PI3K/Akt/mTORC1, and Wnt/β‐catenin pathways.81, 82, 83. The gene discussed is AKT1; the disease is cancer.