A recent study has shown that activated Akt can phosphorylate cytosolic phosphoenolpyruvate carboxykinase 1 (PCK1), that then translocaes to the ER where the phosphorylated PCK1 can bind to, and phosphorylate, INSIG1/2 leading to enhanced lipogenesis in HCC.93 Here, PCK1 is linked to hepatocellular carcinoma.