COX8A and glioblastoma: In glioblastoma (GBM), epithelial growth factor receptor (EGFR) vIII‐activated, PI3K/sterol regulatory element‐binding protein (SREBP) 1‐dependent LDLR upregulation was shown to promote GBM cell survival, while targeting LDLR using nuclear liver‐X‐receptor (LXR) agonists has shown therapeutic value for GBM patients.30