Moreover, this regulation of transcription by positive‐feedback explains: diminished PKC‐ι levels that follow diminished activity of IRS‐1/PI3K and PKC‐ι in muscles of T2DM humans37, 38; and elevated PKC‐ι levels in livers of T2DM humans.18, 19. The gene discussed is PRKCA; the disease is type 2 diabetes mellitus.