The development of cardiovascular problems is abetted by MetS features: (a) hypertension, owing to hyperinsulinemia‐stimulated renal renin release70 and increases in angiotensin‐induced vasoconstriction and aldosterone‐induced sodium retention; and (b) hyperlipidemias, owing to hyperinsulinemia‐stimulated increases in hepatic lipid production. The gene discussed is REN; the disease is hyperinsulinism.