PCK2 and Hyperinsulinemia: Indeed, as discussed, at 3–4 weeks of consuming a 40%‐fat‐kcal HFD, hyperinsulinemia is readily apparent,17 but unaccompanied by alterations in PEPCK/G6Pase; instead, muscle glucose transport is impaired by liver‐to‐muscle cross talk17 and undoubtedly contributes to development of hyperinsulinemia.