The vulnerability of hepatic Akt‐dependent phosphorylation of FoxO1 and PGC‐1α in DIO/MetS/T2DM may reflect the hyperactivation of aPKC in PM areas56, 57 close to sites rich in WD40/ProF53, 54, 55 and PI3K‐dependent PIP3. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.