This later phase of the “obesity/T2DM hepatic phenotype” is depicted in a heat map (Figure 2) that graphically portrays body‐mass‐index (BMI)‐correlated abnormalities in levels and/or activity of insulin‐signaling factors, IRS1, IRS‐2, Akt, and aPKC, and expression, as per mRNA and protein levels of gluconeogenic and lipogenic enzymes in livers of obese and T2DM humans (data from Refs. 17, 18. Here, IRS1 is linked to obesity due to melanocortin 4 receptor deficiency.