In this regard, hepatic mTOR phosphorylation remains elevated in DIO/MetS/T2DM humans even as Akt diminishes,19 suggesting that other factors, for example, aPKCs or other PKCs,60, 61 can activate p70/S6kinase, mTORC1, and SREBP‐1c. This evidence concerns the gene AKT1 and metabolic syndrome.