Further, with the development of hyperinsulinemia and apparent activation of “spare” hepatic insulin receptors, we17, 20, 21, 40, 41, 42, 43 and others46, 47 found that certain insulin‐sensitive pathways in mouse liver are activated in early stages of high‐fat‐feeding, including, Akt. This evidence concerns the gene INS and Hyperinsulinemia.