In turn, hyperinsulinemia increases hepatic activities not only of aPKC and Akt but also the activities of mTORC1 and SREBP‐1c, which are activated by both Akt43, 48, 49 and aPKC.17, 18, 19, 20, 21, 25, 40, 41, 42, 43, 44, 50, 51, 52. This evidence concerns the gene SREBF1 and hyperinsulinism.