The impact of lncRNA TUG1 on HCC cell physiological properties was examined by measuring cell growth, motility, and metastasis in Huh7 cells transfected with OE‐TUG1 + sh‐NC, OE‐NC + sh‐NC, OE‐TUG1 + sh‐ROMO1, and OE‐TUG1 + sh‐USF1. The gene discussed is TUG1; the disease is hepatocellular carcinoma.