Moreover, we measured the epitope‐mutated P5‐3 peptide in the xenograft model, and results demonstrated that there was no significant difference between control group and P5‐3 treatment group (P > .05), while P5 peptide significantly inhibited the tumor growth (Figure 1G‐I), indicating that replacement of the active amino acids affected the activity of the P5 peptide in vivo. This evidence concerns the gene TP53 and neoplasm.