PE‐Sor (COL25A1, TGFB1, DACT1, RBP5, PRKD2, GC, ELF5, LHX8 and SCNN1A) was used to predict sorafenib response in hepatocellular carcinoma (HCC) patients. The gene discussed is COL25A1; the disease is hepatocellular carcinoma.