SREBF1 and hepatocellular carcinoma: As shown by quantitative RT‐PCR results, mRNAs of enzymes required for de novo lipogenesis ACC and FAS as well as their upstream transcription factors SREBP1c, PPARγ, and carbohydrate response element binding protein (ChREBP) were significantly upregulated in human HCC compared to control liver (Figures 2B‐E and S1).